John Leung, MD

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Titles: Founding Physician & CEO, Adjunct Associate Professor in the Department of Medicine and Department of Pediatrics at Tufts Medical Center, Adjunct Associate Professor at Friedman School of Nutrition Science and Policy at Tufts University,
Departments: Allergy, Asthma, Immunology, Food Allergy, Gastroenterology
Appt. Phone: 617-804-6767

Clinical Focus Areas: Allergic rhinitis (seasonal allergy), anaphylaxis, angioedema, asthma, celiac disease, chronic urticarial (hives), drug allergies, eczema, eosinophilic esophagitis/eosinophilic gastrointestinal disorders, food allergy (e.g. peanuts, cow milk, soy, etc.), food intolerance (lactose, fructose, fructan), food protein-induced enterocolitis syndrome (FPIES), immunodeficiency, oral allergy syndrome, pruritus, sinusitis, stinging insect allergy, wheat hypersensitivity

Research Focus Areas: Eosinophilic esophagitis and eosinophilic gastrointestinal disorders, IgE mediated food allergies (e.g. peanut allergy, cow milk allergy and etc, food protein-induced proctitis/colitis and enteropathy of infancy, food protein-induced enterocolitis syndrome (FPIES, Celiac disease, wheat hypersensitivity, oral allergy syndrome, food-dependent exercise-induced anaphylaxis, lactose and fructose intolerance

Overview

Programs + Specialties: Adult Gastroenterology, Pediatric Gastroenterology + Nutrition Training + Education: University of Michigan Medical School; University of Iowa Hospitals and Clinics; Tufts Medical Center; Massachusetts General Hospital, Harvard Medical School Board Certifications: Internal Medicine, Gastroenterology, Allergy NPI # 1447328711

Patient Reviews

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Honors + Awards

2015, American College of Gastroenterology - SCOPY Award for Best Foreign Language Video, “Chinese Colonoscopy Prep”

2013, FIT Travel Scholarship for the 2013 AAAAI Annual Meeting

2012, FIT Travel Scholarship for the 2012 AAAAI Annual Meeting

2011, First authored manuscript “Colchicine plus ursodiol versus methotrexate plus ursodiol in the treatment of primary biliary cirrhosis: Twenty year follow-up" has been chosen as a top editor’s pick in Clinical Gastroenterology and Hepatology and is featured in GI & Hepatology News, the official newspaper of AGA Institute.

2010, Digestive Diseases Week Poster of Distinction

2010, American Associations of Immunologists Trainee Travel Award

2010, American Associations of Immunologists Block Symposium presentation

2010, Fellowship2Leadership Gastroenterology/Hepatology Fellows' Travel Award

2008, American Gastroenterological Association Academic Skills Workshop Travel Award

2008, Choosing a Career in Academic Gastroenterology and Hepatology Conference Travel Award

2001, National Institutes of Health Summer Internship in Biomedical Research Award

1999, National Science Foundation Summer Internship in Bioengineering Research Award

1999, Phi Kappa Phi Honor Society

1999, Tau Beta Pi Honor Engineering Society

1999, Golden Key National Honor Society

1999, James B. Angell Scholar Award, Dean’s List, Class Honors

1998, James B. Angell Scholar Award, Dean’s List, Class Honors

1997, William J. Branstrom Freshman Prize

1997, James B. Angell Scholar Award, Dean’s List, Class Honors

Publications + National Presentations

  1. Leung J, Beukema KR, Shen AH: Allergic Mechanisms of Eosinophilic Oesophagitis. Best Pract Res Clin Gastroenterol. 2015 Oct;29(5):709-20

  2. Kliewer KL, Venter C, Cassin AM, Abonia JP, Aceves SS, Bonis PA, Dellon ES, Falk GW, Furuta GT, Gonsalves N, Gupta SK, Hirano I, Kagalwalla A, Leung J, Mukkada VA, Spergel JM, Rothenberg M. Should wheat, barley, rye and/or gluten be avoided in a six food elimination diet? J. Allergy Clin. Immunol. 2015.

  3. Safroneeva E, Coslovsky M, Kuehni CE, Zwahlen M, Haas NA, Panczak R, Taft T, Hirano I, Dellon ES, Gonsalves N, Leung J, Bussmann C, Woosley JT, Yan P, Romero Y, Furuta G, Gupta S, Aceves S, Chehade M, Straumann A, Schoepfer AM. Eosinophilic oesophagitis: relationship between quality of life and clinical, endoscopic, and histologic activity. Aliment Pharm Ther. 2015.

  4. Schoepfer AM, Panczak R, Zwahlen M, Kuehni CE, Coslovsky M, Maurer E, Haas NA, Alexander JA, Dellon ES, Gonsalves N, Hirano I, Leung J, Bussmann C, Collins MH, Newbury RO, De Petris G, Smyrk TC, Woosley JT, Yan P, Yang GY, Romero Y, Katzka DA, Furuta GT, Gupta SK, Aceves SS, Chehade M, Blanchard C, Straumann A, Safroneeva E ;International EEsAI Study Group. How Do Gastroenterologists Assess Overall Activity of Eosinophilic Esophagitis in Adult Patients? Am. J. Gastroenterol. 2015.

  5. Schoepfer AM, Straumann A, Panczak R, Kuehni CE, Romero Y, Maurer E, Alexander JA, Hirano I, Gonsalves N, MD, Furuta GT, Dellon ES, Leung J, Moawad FJ, Collins MH, Bussmann C, Netzer P, Zwahlen M, Safroneeva E. International EEsAI Study Group. Dysphagia, behavioral changes, and thoracic pain predict adult patient-reported eosinophilic esophagitis severity. Gastroenterology 2014: 147(6): 1255–1266.e21

  6. Kang D, Schlachter SC, Carruth RW, Kim M, Wu T, Tabatabaei N, Vacas-Jacques P, Shishkov M, Woods K, Sauk JS, Leung J, Nishioka NS, Tearney GJ. Comprehensive confocal endomicroscopy of the esophagus in vivo. Endosc Int. Open 2014 Jul 16;2(03):E135–40

  7. Tabatabaei N, Kang D, Wu T, Kim M, Carruth RW, Leung J, Sauk JS, Shreffler W, Yuan Q, Katz A, Nishioka NS, Tearney GJ. Tethered confocal endomicroscopy capsule for diagnosis and monitoring of eosinophilic esophagitis. Biomed. Opt. Express 2013;5:197–207

  8. Leung J, Katz AJ, Shreffler WG, Yuan Q, Hundal N, Butterworth CA. Tolerance of Baked Milk in Patients with Cow's Milk-mediated Eosinophilic Esophagitis. J Allergy Clin Immunol.2013;132:1215–1216.e1.

  9. Leung J, Guyer A, Banerji A. IgE-mediated hypersensitivity to ondansetron and safe use of palonosetron. J Allergy Clin Immuno. Pr. 2013: 1(5); 536-537

  10. Islam SA, Ling MF, Leung J, Shreffler WG, Luster AD. Identification of human CCR8 as a CCL18 receptor. J Exp Med. 2013 Sep 23;210(10):1889-98

Biography

John Leung, MD attended medical school at University of Michigan Medical School and completed his internal medicine residency at University of Iowa Hospitals and Clinics. He then finished a Gastroenterology fellowship at Tufts Medical Center. He worked as a gastroenterology consultant at Tufts Medical Center for a year before completing an Allergy/Immunology clinical and research fellowship at Massachusetts General Hospital/Harvard Medical School. His clinical and research focus are on eosinophilic esophagitis and food allergy. He has coauthored more than 40 peer-reviewed manuscripts, scientific abstracts, book chapters, and online tutorials.

Professional Memberships

Phi Kappa Phi Honor Society

Tau Beta Pi Honor Engineering Society

Golden Key National Honor Society

OXE Chemical Engineering Honor Society

American Institution of Chemical Engineering Association

American Medical Association

American Family Physicians

American College of Physicians

United Asian American Medical Student Association

American Association of Immunologists

American Gastroenterological Association

American College of Gastroenterology

The Massachusetts Medical Society

New England Endoscopy Society

Society for Mucosal Immunology

American Academy of Allergy Asthma and Immunology

American College of Allergy, Asthma and Immunology

News, Media + Videos

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Research + Clinical Trials

Current Funding

2015 – Grant title: Eosinophilic Esophagitis (EoE) Intervention Trial-Randomized 1 Food Elimination vs. 4 Food Elimination Diet followed by Swallowed Glucocorticoids Funding Source: PCORI Role: Site Principal investigator

2015 – Grant title: Decreasing Asthma-Related Healthcare Costs through Tele-Asthma Management Funding Source: LCO 2015 Performance and System Improvement Program Role: Principal investigator

2015 – Grant title: A Phase III, Randomized, Placebo-Controlled Clinical Trial to Study the Efficacy and Safety of MK-3641, a Ragweed (Ambrosia artemisiifolia) Sublingual Immunotherapy Tablet, in Children With a History of Ragweed-Induced Rhinoconjunctivitis With or Without Asthma Funding Source: Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc. ClinicalTrials.gov ID: NCT02478398 Role: Site Principal investigator

2014 – Grant title: A Randomized, Double-Blind, Parallel, Placebo-Controlled Study of the Efficacy, Safety and Tolerability of Dupilumab in Adult Patients with Active Eosinophilic Esophagitis Funding source: Regeneron Pharmaceuticals Inc. Role: Site Principal investigator

2014 – Grant title: Consortium of Eosinophilic Gastrointestinal Disease Researchers Website: https://www.rarediseasesnetwork.org/CEGIR/index.htm Funding Source: National Institutes of Health Grant number: 1U54AI117804-01 Role: Site Principal investigator

2011–14 Grant title: Development, Validation and Evaluation of an Adult and Pediatric Eosinophilic Esophagitis Activity Index: A Prospective Multicenter Study Funding Source: Swiss National Science Foundation (grant no. 32003B_135665/1), AstraZeneca AG (Switzerland), Aptalis, Dr. Falk Pharma GmbH (Germany), Glaxo Smith Kline AG, Nestlé S. A. (Switzerland), The International Gastrointestinal Eosinophil ResearcherS (TIGERS). ClinicalTrials.gov ID: NCT00939263 Role: Site Principal investigator Past Funding

2012-14 Grant title: OBS in Adolescent and Young Adults With EOE: A Phase II, Randomized, Double-Blind, Placebo Controlled, Study With an Open Label Extension Funding Source: Meritage Pharma, Inc. ClinicalTrials.gov ID: NCT01642212 Role: Site Principle investigator

2010-11 Grant title: Assessment of Fractionated exhaled Nitric Oxide (FeNO) as a biomarker for the treatment of eosinophilic esophagitis ClinicalTrials.gov ID: NCT01170234 Funding Source: TIGERS Concept Awards (75K), Tufts CTSI Pilot Studies Program Award (15K) Role: Principle investigator

2010-11 Grant title: Effects of Enteric Helmith Infection on Gut Inflammation in a Murine Model of Food Hypersensitivity Funding Source: Tufts Medical Center Research Award (50K) Role: Principle investigator

Community Commitments

Advisory board member for Wang YMCA, Boston, MA (2014-Present)

Health Advisory Council of a regional newspaper Sampan, Boston (2014-Present)